Plos pathogens: New hope for influenza prevention and treatment: You can prevent influenza without vaccination


Release time:

2018-05-24

Recently, researchers from The Ohio State University in the United States have discovered a new method that can trigger the body's protective response to influenza virus infection without the action of viruses or interferons. Relevant research results were published in the international academic journal plos pathogens.

  Recently, researchers from The Ohio State University in the United States have discovered a new method that can trigger the body's protective response to influenza virus infection without the action of viruses or interferons. Relevant research results were published in the international academic journal plos pathogens.

  The researchers pointed out: "Because influenza viruses continue to mutate, the influenza vaccines developed every year need to make corresponding changes, and the work we have done targets a more basic process rather than targeting a specific virus. type."

  The new method works by increasing the expression levels of a protein called IFITM3 that previous studies have found to be effective against all influenza virus subtypes tested. The key to preventing infection through this method is to promote the expression level of this protein before the virus emerges.

  Under natural conditions, IFITM3 is only produced in large quantities after the influenza virus appears. It can trap the virus and weaken the virus's ability to replicate itself, thereby reducing the damage caused by infection. When the function of IFITM3 is needed, all cells can produce this protein to maintain the short-term stable existence of IFITM3. However, the lifespan of the IFITM3 protein is very short. Once the cell does not need the protein to perform its antiviral function, it will be degraded. Once the influenza virus invades cells, the cells will produce interferon. Under the action of interferon, the expression of IFITM3 will increase. This suggests that increasing expression levels of this protein before the virus emerges may prevent the onset of viral infection.

  Therefore, in this study, the researchers inhibited the action of a ubiquitinase (NEDD4) that promotes the degradation of IFITM3, causing IFITM3 to accumulate in cells, and then used influenza virus to infect the cells. It was found that due to the accumulation of IFITM3, Cells develop resistance to viruses.

  Overall, this study found that removing the pro-degradative effect of ubiquitinase NEDD4 on IFITM3 can effectively prevent influenza virus infection. Applying this method can inhibit influenza virus without viral infection or interferon stimulation, but when How to remove the ubiquitinase NEDD4 remains a question and more research is needed.

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