Gene-edited stem cells could eliminate HIV
Release time:
2018-04-20
Using gene-edited bone marrow stem cells can significantly reduce the size of dormant "viral reservoirs" in pig-tailed macaques infected with simian/human immunodeficiency virus (SHIV), Christopher Peterson of the Fred Hutchinson Cancer Research Center and colleagues report in PLOS The latest research was published in Pathogens.
Using gene-edited bone marrow stem cells can significantly reduce the size of dormant "viral reservoirs" in pig-tailed macaques infected with simian/human immunodeficiency virus (SHIV), Christopher Peterson of the Fred Hutchinson Cancer Research Center and colleagues report in PLOS The latest research was published in Pathogens.
Photo credit: Grace Choi
In 2007, HIV-positive Timothy Brown received a bone marrow stem cell transplant to treat leukemia. This process accidentally cleared HIV from his body, possibly due to mutations in the CCR5 gene of the donor cells, which made him resistant to HIV. But finding donors with CCR5 mutations is difficult, and such transplants are very dangerous for healthy HIV-positive patients because the donor cells have the potential to attack their own cells.
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